1. The genetic disorder occurs in individuals who are homozygotic for the mutated gene. （这种遗传疾病发生在基因突变的纯合子个体中。）
2. The study aimed to determine the prevalence and clinical manifestations of homozygotic sickle cell disease. （该研究旨在确定纯合子镰状细胞病的患病率和临床表现。）